The challenges facing the domestic economy in the conditions of the third industrial revolution predict enhancing the capacity for the development and implementation of modern principles of organizational and technological nature. Study of the interaction between universities, administrative authorities and the business is currently hampered by the lack of empirical data and the difficulty in organizing this process. The paper traced the evolution of the classical university in research institution and identifies signs of an enterprising university. The paper provides definitions of university technology transfer process. A version of establishing external links between a university and regional business is described. The ways of implementing the innovation strategy of the University and a mechanism to optimize the management structure of the university in order to reduce financial costs for the maintenance of the innovation infrastructure are described. For the normal functioning of an innovation system of the university it is necessary to allocate the infrastructure innovation in a separate unit with its  own  income and expenses balance. To efficiently manage its performance it is necessary to select an indicator based on the intellectual capital sales revenue to encourage its increase. The independent activities of an innovation infrastructure of the university has a positive effect on the overall functioning of the university and its place in the universities ranking.